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Molecular Genetics: Deadly Mutations 222 Views
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Description:
In this video from our course on molecular genetics, learn all about deadly mutations.
Transcript
- 00:00
Thank you We sneak in Molecular genetics Dangerous mutations shmoop
- 00:13
so a lot of mutations or bad hemophilia Tay sachs
- 00:17
cancer Ric you're an expert in how does that work
- 00:21
Meaning I remember reading about sickle cell anemia existed in
- 00:26
africa because it fought malaria very well And it let
Full Transcript
- 00:29
you live to about twenty five years old to just
- 00:32
reproduce And then it would kill you like and so
- 00:36
some of these things you understand genetically why they exist
- 00:39
because it let the person replicate But then they passed
- 00:42
on the bad gene Why do we have bad mutations
- 00:47
You know that's a great question Why do mutations even
- 00:49
persist if they're so detrimental in some cases there's Some
- 00:52
benefit that we might not know that for example sickle
- 00:54
cell people have one copy One bad copy The genius
- 00:57
resistant to malaria too Bad copies You're gonna get sickle
- 01:00
cell anemia In other cases musicians just happened for no
- 01:04
reason And they're bad It's Not like a weren't selected
- 01:07
for but you happen to get them through bad luck
- 01:09
And so you have a disease That was it How
- 01:12
do we get deadly mutations How does that work Is
- 01:15
it just kind of a crap shoot in the way
- 01:20
We were of all yes mutations can arise in a
- 01:22
couple of ways One is that there are some rice
- 01:25
which is then time net replicant today And it just
- 01:27
makes mistakes sometimes it's pretty good but sometimes their mistakes
- 01:29
that don't get fixed And why does it make a
- 01:31
mistake Like what would be the cause Or is it
- 01:33
just there's so many of them Eventually you're gonna have
- 01:36
someone transcribed the number wrong Yeah i think both of
- 01:38
those are right So sometimes yeah it has to replicate
- 01:41
you know billions of nucleotides every time a cell divides
- 01:44
Also there are certain places where it tends to slip
- 01:46
So let's say there's a bunch of teas in a
- 01:48
row it's possible the sunrise We'll lose track and not
- 01:50
realize what it where it is A kind of slipped
- 01:52
back and re duplicate that so there's certain hot spots
- 01:55
of mutations But then also they're totally random at times
- 01:59
But you could also get mutations externally So from the
- 02:01
sun we know that you be could damage your skin
- 02:04
computations tobacco smoke vacation so it can kind of be
- 02:08
internal or external And the how you cope with that
- 02:12
I mean certainly different people cope differently But certain mutations
- 02:15
are going to just one hundred percent cause certain diseases
- 02:19
So for example if you have a taste expedition you're
- 02:21
gonna get yeah Why do we have bad mutations How 00:02:30.42 --> [endTime] do we get deadly mutations
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